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After defending his doctoral thesis at the Ecole polytechnique (IP Paris) in 2008, for which he was awarded the Ecole's thesis prize, Matías Núñez continued his research as a postdoctoral fellow at Université de Montréal. At the start of the 2009 academic year, he joined the CNRS, where he was first posted to University of Cergy-Pontoise, then to University of Paris-Dauphine. Since 2020, he has been a permanent member of CREST and a professor at Ecole polytechnique.
Throughout his career, he has spent a great deal of time in leading international research centres, particularly in the United States (Berkeley, Caltech, Rochester). His work focuses on political economy, in particular mass elections, the development of innovative methods of collective decision-making and, more recently, experimental economics.