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Immortality, an ancient fantasy revived by transhumanism

Stéphane Charpier
Stéphane Charpier
Professor of Neuroscience at Sorbonne University and Research Director at Institut du cerveau de Paris
Cécilia Calheiros
Cécilia Calheiros
PhD in sociology, specialist in transhumanism
Key takeaways
  • Transhumanism is a school of thought that promotes the idea of surpassing the human condition.
  • With life expectancy rising steadily over the last few decades, advances in neuroscience are bringing the ideological aspects of this school of thought to light.
  • Over the centuries, the definition of death has evolved considerably, but today it is considered to be the absence of brain activity.
  • Researchers have identified distinctive signals associated with death and resuscitation, making the definition of death more complex from a neurophysiological point of view.
  • Now, some transhumanist movements are no longer aiming for immortality, but amortality, i.e. a considerably prolonged life in good health.
  • Immortality is a long-standing human goal, but what is new is the techno-scientific justification for this ambition.

From being “brain dead” to the “mind down­load” envis­aged by transhuman­ists, the bound­ary between life and death con­tin­ues to be shrouded in mys­tery. But in the face of the hopes of immor­tal­ity that they raise, the lim­its of sci­entif­ic real­ity and the human con­di­tion must be faced. Recent advances in neur­os­cience have led to a rejec­tion of this desire to “kill death”, which has more to do with ideo­logy than with a ser­i­ous techno-sci­entif­ic project.

Thanks to advances in sci­ence and medi­cine, human­ity has nev­er ceased to delay its own demise. While a con­tem­por­ary of Char­le­magne was born with a life expect­ancy of barely 30 years, INED pre­dicts that a cit­izen of the European Uni­on born in 2022 will live an aver­age of just over eight dec­ades. But some people ima­gine going even fur­ther. Recent sci­entif­ic revolu­tions in arti­fi­cial intel­li­gence, genet­ics, bio­logy and neur­os­cience, com­bined with the emer­gence of transhuman­ism (a move­ment that pro­motes the idea of tran­scend­ing the human con­di­tion), have brought the quest for immor­tal­ity back to centre stage, or at least for a sig­ni­fic­ant exten­sion of life.

But before we can under­stand how and why we delay death, we need to be able to define it. And the ques­tion is not so simple: “As a sci­ent­ist, I don’t know what death is”, admits Stéphane Charpi­er, pro­fess­or of neur­os­cience at Sor­bonne Uni­ver­sity and dir­ect­or of the Brain Neur­os­cience team at Inserm. For him, it is a “primary concept” that only takes on mean­ing in oppos­i­tion (“in the neg­at­ive”) to life. This is why his work involves “study­ing death by try­ing to under­stand what is hap­penng in a brain that is still alive”.

A case of brain death described by P. Mol­laret and M. Goulon in 1959, in the Revue Neur­o­lo­gique. The authors go on to point out that “the sur­viv­al of such a patient auto­mat­ic­ally ceases as soon as res­pir­at­ory or cir­cu­lat­ory con­trol is stopped”

The corpse with the beating heart

The idea that a human being with a beat­ing heart is neces­sar­ily alive is still widely held. How­ever, when Pierre Mol­laret and Maurice Goulon dis­covered brain death1 in the middle of the 20th cen­tury, they dis­proved this prin­ciple and “engendered,” accord­ing to Stéphane Charpi­er, “a new status of human exist­ence”, by describ­ing the pos­sib­il­ity of hav­ing a corpse with a beat­ing heart, but whose brain has been des­troyed. The two resus­cit­at­ors were in fact the first to con­cep­tu­al­ise the prin­ciple of brain death. They defined this status as a “coma in which, in addi­tion to the total abol­i­tion of the func­tions of rela­tion­al life (editor’s note: absence of mus­cu­lar and nervous react­iv­ity), there is not only dis­turb­ance, but also total abol­i­tion of veget­at­ive life (editor’s note: absence of spon­tan­eous respiration)”.

In this way, the car­diocentric vis­ion of exist­ence is no longer rel­ev­ant and, from a med­ic­al point of view, what makes a human being not dead is no longer his beat­ing heart, but his liv­ing brain.

Since 2012, the WHO has also adop­ted this brain-cent­ric view­point in its defin­i­tion of death: “the per­man­ent and irre­vers­ible dis­ap­pear­ance of the capa­city for con­scious­ness and of all func­tions of the brain stem”. A human being is there­fore con­sidered to be alive as soon as his or her brain is cap­able of gen­er­at­ing “elec­tric­al back­ground noise”, as Stéphane Charpi­er points out. This phe­nomen­on, which res­ults from the brain’s spon­tan­eous, endo­gen­ous activ­ity, can be meas­ured using an elec­tro­en­ceph­al­o­gram or micro­elec­trodes that sci­ent­ists insert inside neurons.

Immortality, the permanent horizon of transhumanism

Elec­tro-neur­on­al stud­ies enable research­ers to “dif­fer­en­ti­ate three physiolo­gic­al dimen­sions of exist­ence: liv­ing, awake and con­scious”, to which par­tic­u­lar elec­tric­al sig­na­tures cor­res­pond. As Stéphane Charpi­er, author of La sci­ence de la résur­rec­tion2, explains, this trip­tych makes it pos­sible to under­stand that “what makes a human being not dead is no longer just his beat­ing heart, or his abil­ity to breathe spon­tan­eously, but his capa­city to pro­duce a con­scious sub­ject­ive experience.”

So, if death coin­cides with the inab­il­ity to be con­scious, does the quest for immor­tal­ity cher­ished by transhuman­ists amount to keep­ing our brains alive after our bod­ies have failed us? “Not exclus­ively,” replies Cecil­ia Cal­heir­os, a soci­olo­gist spe­cial­ising in health and reli­gion who devoted her doc­tor­al thes­is to the sub­ject. “Transhuman­ism aims for the end of the human as it exists and the advent of a new one,” she sums up, “which will be either immor­tal or amor­t­al, depend­ing on wheth­er you’re a North Amer­ic­an or French transhuman­ist.” By amor­t­al, we mean a human being whose lifespan in good health is con­sid­er­ably exten­ded, without being etern­al. In short, the transhuman­ist pro­ject amounts to pro­pos­ing a soci­ety where “the human con­di­tion frees itself from its bio­lo­gic­al limits”.

The wave of death is not fatal

In 2011, bored by a sci­entif­ic present­a­tion at a con­fer­ence, Stéphane Charpi­er chose to read an art­icle pub­lished in the journ­al Plos One3, the title of which men­tions a mys­ter­i­ous “Wave of Death”. In it, the authors assess the brain activ­ity that occurs at the moment of death, “by study­ing what hap­pens in the brain of a rat before, dur­ing and after decap­it­a­tion”, he explains. And, as expec­ted, “they found that this activ­ity died out very quickly, but that after a while a gigant­ic wave appeared on the elec­tro­en­ceph­al­o­gram, which had flattened out!” This is what the Dutch research­ers call the “wave of death”, sug­gest­ing that it is the last sig­nal a brain pro­duces before it finally shuts down.

Noth­ing less was needed to arouse the neuroscientist’s curi­os­ity, and to get his Inserm team at the Insti­tut du Cerveau (Pitié Sal­pet­rière Hos­pit­al in Par­is) involved in a pro­ject to study this phe­nomen­on in great­er detail. “We aban­doned the prin­ciple of decap­it­a­tion and set up a pro­tocol enabling us to switch off the brain, then rean­im­ate it after­wards, while study­ing brain activ­ity using micro­elec­trodes inser­ted into the neur­ons of our test sub­ject,” sums up the researcher.

Elec­tro-cor­tico­graph­ic (EcoG) meas­ure­ments in rats, after induced Anox­ia onset and a resus­cit­a­tion attempt. In fig­ure A, the upper tra­cings show suc­cess­ful resus­cit­a­tion and the onset of the resus­cit­a­tion wave (WoR). (Mod­i­fied from Schramm et al., 2020). Source: Charpi­er S (2023)4.

After con­firm­ing the neur­on­al phe­nomen­on of the wave of death, when the test sub­jects were rean­im­ated, the research­ers wit­nessed the appear­ance of “a second wave! […] An elec­tric­al sign of the brain’s return to life”, which they named the “rean­im­a­tion wave”. The sci­ent­ists have thus char­ac­ter­ised two neur­on­al mark­ers that help decipher the bound­ary between life and death. Para­met­ers are still lack­ing to define death pre­cisely from a neuro­physiolo­gic­al point of view, but their work makes it pos­sible to attrib­ute a sig­na­ture to two dis­tinct states: “I may be dying” and “I may be com­ing back”.

A flat elec­tro­en­ceph­al­o­gram doesn’t neces­sar­ily mean that everything is over, which is why Stéphane Charpi­er says that “death is an asymp­tote”. A curve whose point of con­ver­gence with the end line is a more than inde­cis­ive horizon.

An illusion of eternity

Accord­ing to those who claim to be part of this move­ment, immor­tal­ity is only a “speck on the hori­zon” for the time being. To achieve it, some transhuman­ists advoc­ate a bio­lo­gic­al approach to counter-aging (or “‘longev­ity”), with the aim of halt­ing or even revers­ing the aging pro­cess. Oth­ers believe that “true free­dom con­sists in detach­ing one­self from one’s phys­ic­al body”, says the research­er. In this case, the essence of exist­ence lies in the brain, whose memor­ies and func­tion­ing should be pre­served “to make it imper­ish­able” by cryo­gen­ics, as pro­posed by the Alcor Life Exten­sion Found­a­tion in the USA, or by mind upload­ing pro­cesses. While these meth­ods fail to approach the realm of the pos­sible, they do have the advant­age of fuel­ing the ima­gin­a­tions of many artists and sci­ence-fic­tion writers.

Bor­is Kar­loff in the role of the mon­ster (pub­li­city photo for the film Bride of Franken­stein, 1935).

Illus­ory, then? “Without a doubt,” says Stéphane Charpi­er. In his view, “the transhuman­ist pro­ject is a meta­phys­ic­al fable. We can increase our life expect­ancy, cor­rect defects and com­pensate for cer­tain weak­nesses, but increas­ing the human being as an entity, or cryo­gen­ic­ally stor­ing their brain, is quite simply a pipe dream.” The neur­os­cient­ist acknow­ledges that humans are cap­able of pro­du­cing arti­fi­cial neur­al net­works, of “tinker­ing with brains”, but con­siders it unima­gin­able that a machine could pro­duce, or even rep­lic­ate, the neur­al pro­cesses under­ly­ing subjectivity.

The means justify the end

Ulti­mately, the innov­at­ive char­ac­ter of transhuman­ism does not lie in the quest for etern­al life. “What is new is the asser­tion that immor­tal­ity is plaus­ible, thanks to a dis­course based on techno-sci­entif­ic advances. Transhuman­ist object­ives are thus con­vin­cing play­ers in key spheres of our soci­et­ies: industry, research, health, etc.”, points out Cecil­ia Cal­heir­os. As a res­ult, transhuman­ism is, in her view, “the most exacer­bated expres­sion of neo­lib­er­al soci­ety, which urges every­one to be the best ver­sion of them­selves and to con­stantly improve their skills.” The soci­olo­gist sees this move­ment “above all as an ideo­logy, which rein­forces a power that is already present.”

In the transhuman­ist con­text, the max­im that the end jus­ti­fies the means no longer holds true, since this end (death) is destined to dis­ap­pear. The transhuman­ist myth is based on a reverse move­ment in which the means (tech­nos­ciences) jus­ti­fy a new end (immortality/amortality). The ambi­tion is “infin­ite mas­tery of the world” and of the bio­lo­gic­al con­di­tions of exist­ence, which brings transhuman­ists back to the myth of Franken­stein, accord­ing to Stéphane Charpi­er. In his view, “with this nov­el, Mary Shel­ley wrote the first transhuman­ist text. She ima­gines a body made of frag­ments of corpses that lives and ful­fills the dream of transhuman­ists: to deprive human beings of death.”

The quest for immor­tal­ity and longev­ity has punc­tu­ated the his­tory of man­kind since its earli­est begin­nings. It is embod­ied in count­less myths about mor­tals who dared to aspire to the immor­tal­ity of the gods and were con­demned to tor­ment in return (Pro­meth­eus, Icarus, etc.). The rise of transhuman­ism is a mod­ern update of this ambi­tion. Unfin­ished, this move­ment comes up against the wall of objectiv­ity and the sci­entif­ic approach. “Can we be con­scious without a body? Can a machine really pro­duce sub­jectiv­ity?” asks Stéphane Charpi­er rhet­or­ic­ally, by way of conclusion.

As long as transhuman­ists can’t provide an object­ive demon­stra­tion or proof that it’s pos­sible, death will remain the shared hori­zon for each and every one of us.

Samuel Belaud
1http://​site​.jerome​coste​.free​.fr/​a​r​t​i​c​l​e​s​/​M​o​l​l​a​r​e​t​1​9​5​9.pdf
2https://​edi​tions​.flam​mari​on​.com/​l​a​-​s​c​i​e​n​c​e​-​d​e​-​l​a​-​r​e​s​u​r​r​e​c​t​i​o​n​/​9​7​8​2​0​8​1​5​03335
3https://​www​.ncbi​.nlm​.nih​.gov/​p​m​c​/​a​r​t​i​c​l​e​s​/​P​M​C​3​0​2​9360/
4Between life and death: the brain twi­light zones. Front. Neur­osci. 17:1156368

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